Understanding blood cancers and treatment options

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What are bone marrow and blood cancers?

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Healthy blood cells include a balance of different cell types.

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Most blood cancers, also called hematologic cancers, start in the bone marrow, which is where blood is produced. Blood cancers occur when abnormal blood cells start growing out of control, interrupting the function of normal blood cells, which fight off infection và produce new blood cells.

This article will cover:


Types of blood cancer

The three main types of blood and bone marrow cancer are leukemia, lymphoma & myeloma:

There are also less common forms of blood and bone marrow cancers, or associated disorders, including:

Myeloproliferative neoplasms (MPNs): These rare blood cancers occur when the body overproduces white blood cells, red blood cells or platelets. The three main subcategories are essential thrombocythemia (ET), myelofibrosis (MF) và polycythemia vera (PV). Amyloidosis: This rare disorder, characterized by the buildup of an abnormal protein called amyloid, is not a form of cancer. But it is closely associated with multiple myeloma. Aplastic anemia: This rare condition occurs when key stem cells are damaged & can only be treated with a bone marrow transplant.

Blood cancer symptoms

Some common bone marrow & blood cancer symptoms include:

Fever, chills Persistent fatigue, weakness Loss of appetite, nausea Unexplained weight loss Night sweats Bone/joint pain Abdominal discomfort Headaches Shortness of breath Frequent infections Itchy skin or skin rash Swollen lymph nodes in the neck, underarms or groin

Causes of blood cancer

All blood cancers are caused by mutations in the genetic material—the DNA—of blood cells. Other risk factors vary based on the specific type of blood cancer.

Risk factors for developing acute myeloid leukemia (AML), the most common khung of leukemia in adults, include:

Advancing age Gender: being male Exposure khổng lồ industrial chemicals such as benzene Smoking History of cancer treatment Exposure to high doses of radiation History of other blood cancers

Risk factors for developing Hodgkin lymphoma include:

History of infection with Epstein-Barr virus (EBV), which causes infectious mononucleosis (mono) Advancing age Gender: Being male Family history of Hodgkin lymphoma Compromised immune system

Risk factors for developing non-Hodgkin lymphoma include:

Exposure lớn certain industrial chemicals, herbicides and insecticides History of chemotherapy Radiation exposure Compromised immune system History of autoimmune diseases such as rheumatoid arthritis or lupus

Risk factors for developing multiple myeloma include:

Advancing age Gender: Being male Race: Higher risk among African-Americans Obesity or extra toàn thân weight

How is blood cancer diagnosed?

Determining a diagnosis often starts with a physical examination to kiểm tra your general health. Your doctor will reviews your health history, examine your toàn thân and lymph nodes, và look for any signs of infection or bruising.

Different types of tests & procedures may be used khổng lồ diagnose blood cancer. What you need will depend on the type of blood cancer suspected. Your care team may recommend testing và evaluate all the results along with you khổng lồ make a diagnosis.

Biopsies

A biopsy is a thử nghiệm that collects samples of cells for examination by a pathologist in a laboratory. For some types of blood cancer, lượt thích lymphoma, you may need a lymph node biopsy that obtains a sample of lymph tissue or an entire lymph node.

Testing your bone marrow, where blood cells are formed, can help diagnose certain types of blood cancer. Doctors use a procedure called a bone marrow aspiration khổng lồ remove a small sample of bone marrow, blood và bone from either a hip bone or breastbone. The sample is sent lớn a lab and checked for abnormal cells or changes in genetic material.

Imaging scans

Imaging scans are more helpful for some types of blood cancer than others. A scan may spot an enlarged lymph node, which is a common symptom of lymphoma, but it’s not usually used to diagnose leukemia, a blood cancer that doesn’t cause visible tumors. Still, scans may help whether cancer has affected other parts of the body.

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Scans include:

Certain types of scans are used during biopsies lớn help pinpoint the area khổng lồ be sampled.

Blood tests

A complete blood count (CBC)shows the cell count of different components of blood, such as white blood cells, red blood cells and platelets.

Blood chemistry tests measure levels of key substances in your blood. Abnormal levels of certain proteins, for example, may offer information about your condition. If multiple myeloma is suspected, doctors may want to check your blood calcium level. For possible lymphoma, an enzyme called lactate dehydrogenase (LDH) may be measured.


Blood cancer treatment & therapy options

Treatment for blood & bone marrow cancers depends on the type of cancer,your age, how fast the cancer is progressing, where the cancer has spread and other factors. Some common blood cancer treatments for leukemia, lymphoma, & multiple myeloma include:

Stem cell transplantation: A stem cell transplant infuses healthy blood-forming stem cells into the body. Stem cells may be collected from the bone marrow, circulating blood & umbilical cord blood.

Chemotherapy: Chemotherapy uses anticancer drugs to interfere with and stop the growth of cancer cells in the body. Chemotherapy for blood cancer sometimes involves giving several drugs together in a mix regimen. This treatment may also be given before a stem cell transplant.

Radiation therapy: Radiation therapy may be used khổng lồ destroy cancer cells or to lớn relieve pain or discomfort. It may also be given before a stem cell transplant.

Learn more about leukemia treatments, Hodgkin lymphoma treatments, non-Hodgkin lymphoma treatmentsand multiple myeloma treatments


Blood cancer survival rates

A blood cancer prognosis varies based on the type & other factors, including your overall health, age và response lớn treatment.

According lớn the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) Program, the five-year relative survival rate (the percentage of people who were still alive five years after diagnosis) is 65 percent for leukemia—a number that has improved dramatically in the past 50 years. Other rates include:

Keep in mind that these survival rates are estimates, based on historical data & past treatments. Advances in medicine may make your experience even more hopeful.